Change of address
3 months ago in Variety of Life
Discussions on the interface between Science and Society, Politics, Religion, Life, and whatever else I decide to write about.
| Monday, November 16, 2009 | ||
| 7:30pm - 9:30pm 
 | 

 First, you need to know about neutrophils. In short, neutrophils are  one of the asskicking cells of the immune system (this is the system that has allowed you to live long enough to read this). When you are infected (and you are currrently infected with a bunch of things), your cells recruit neutrophils and other immunologic cells to the sites of infection to basically go ape-shit on the infectious particle's ass. Neutrophils are the kamikaze fighters of your immune system. While I am in fact being metaphorical here, in many ways the kamikaze analogy holds up well. When combatting infectious agents, such as bacteria or fungi, neutrophils act like suicide bombers secreting enzymes that are destructive or make destructive toxic chemicals that kill the infecting particle and the neutrophil (for the record the primary component of pus, the gunk you squeeze out of your forehead when combatting zits) is basically the carcasses of dead neutrophils that gave up their lives to the cause).
First, you need to know about neutrophils. In short, neutrophils are  one of the asskicking cells of the immune system (this is the system that has allowed you to live long enough to read this). When you are infected (and you are currrently infected with a bunch of things), your cells recruit neutrophils and other immunologic cells to the sites of infection to basically go ape-shit on the infectious particle's ass. Neutrophils are the kamikaze fighters of your immune system. While I am in fact being metaphorical here, in many ways the kamikaze analogy holds up well. When combatting infectious agents, such as bacteria or fungi, neutrophils act like suicide bombers secreting enzymes that are destructive or make destructive toxic chemicals that kill the infecting particle and the neutrophil (for the record the primary component of pus, the gunk you squeeze out of your forehead when combatting zits) is basically the carcasses of dead neutrophils that gave up their lives to the cause). Bananaman's idea of god, of course the little thing on top is either the holy spirit or Bananaman himself, I get confused.
Bananaman's idea of god, of course the little thing on top is either the holy spirit or Bananaman himself, I get confused. It is an artifically selected beast derived from something akin to this:
It is an artifically selected beast derived from something akin to this:

 Science: a natural philosophical approach to understanding the universe and all that is in it. The underlying supposition of science is that the universe can be understood without appeal to supernatural mechanisms. (The way in which science is done is well well well beyond the scope of a single blog, much less a blog post!)
Science: a natural philosophical approach to understanding the universe and all that is in it. The underlying supposition of science is that the universe can be understood without appeal to supernatural mechanisms. (The way in which science is done is well well well beyond the scope of a single blog, much less a blog post!) Religion: a belief system that encompasses faith as an approach to understand the universe. The underlying supposition of religion is that the universe can be understood by revelation. (Revelation contains personal revelation, revelation from a church leader, and revelation from religious texts.)
Religion: a belief system that encompasses faith as an approach to understand the universe. The underlying supposition of religion is that the universe can be understood by revelation. (Revelation contains personal revelation, revelation from a church leader, and revelation from religious texts.)
 OK, lets take a hypothetical example. In the species of blue-butted gnus, two proteins (A and B) interact to make the blue pigment in said gnus butts. In the first couple of blue-butted gnus we studied, we saw that the gnus had alleles A1 and B1 of these proteins and of course their butts were blue. However, we looked at several other gnus and identified alleles A2 and B2 of these proteins. Upon closer examination, we find lots of A1B1 gnus and a few A1B2 and A2B1 gnus, but no A2B2 gnus. That seems odd, so as junior scientist-heroes, we grab an A1B2 animal and mate it to an A2B1 animal and find out that low and behold we can get an A2B2 animal!!!11!1 But HOLY SHIT, it has a green butt! Did we just make a new species of green-butted gnus? Sadly, we find that gnus, regardless of butt color only want to mate with blue-butted gnus with blue butts. So, no gnus will mate with a green-butted gnu, which as you know is not good news for the green-butted gnu. Now the A2 and B2 alleles do not matter at all, except when combined together, so this has the effect that gnus with the A2 or B2 alleles tend to become isolated, the A2 gnus tend to be at the left hand side of the field over by the swamp, whereas the B2 gnus are found more often at the other side of the field near the woods. What we've done is begun to genetically isolate populations. So although all blue-butted gnus can mate, green-butted gnus are immediately removed from the population. Of course random drift can lead to the complete loss of either A2 or B2, which would end this discussion. However, additional random mutations can and will occur and genetic drift now has a mechanism that can further genetically isolate these gnus into distinct, but spatially overlapping populations. Give me another 40,000 years and a glass of wine and Ill give you two species of gnus: the swampland blue-butted gnu and the woodland blue-butted gnu.
OK, lets take a hypothetical example. In the species of blue-butted gnus, two proteins (A and B) interact to make the blue pigment in said gnus butts. In the first couple of blue-butted gnus we studied, we saw that the gnus had alleles A1 and B1 of these proteins and of course their butts were blue. However, we looked at several other gnus and identified alleles A2 and B2 of these proteins. Upon closer examination, we find lots of A1B1 gnus and a few A1B2 and A2B1 gnus, but no A2B2 gnus. That seems odd, so as junior scientist-heroes, we grab an A1B2 animal and mate it to an A2B1 animal and find out that low and behold we can get an A2B2 animal!!!11!1 But HOLY SHIT, it has a green butt! Did we just make a new species of green-butted gnus? Sadly, we find that gnus, regardless of butt color only want to mate with blue-butted gnus with blue butts. So, no gnus will mate with a green-butted gnu, which as you know is not good news for the green-butted gnu. Now the A2 and B2 alleles do not matter at all, except when combined together, so this has the effect that gnus with the A2 or B2 alleles tend to become isolated, the A2 gnus tend to be at the left hand side of the field over by the swamp, whereas the B2 gnus are found more often at the other side of the field near the woods. What we've done is begun to genetically isolate populations. So although all blue-butted gnus can mate, green-butted gnus are immediately removed from the population. Of course random drift can lead to the complete loss of either A2 or B2, which would end this discussion. However, additional random mutations can and will occur and genetic drift now has a mechanism that can further genetically isolate these gnus into distinct, but spatially overlapping populations. Give me another 40,000 years and a glass of wine and Ill give you two species of gnus: the swampland blue-butted gnu and the woodland blue-butted gnu.
 LIFE: A Journey Through Time
LIFE: A Journey Through Time